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Multinucleotide variant (MNV)

Definition
AI-generated

A multinucleotide variant (MNV) is a local haplotype of multiple substituted bases treated as one allelic change rather than independent SNPs.

Topics
Sequencing Data Analysis
Related
Indel Single Nucleotide Variant (SNV) Variant normalization

Why it matters in GWAS

MNVs need distinct normalization and annotation; miscalling them as separate SNPs can break LD-based fine-mapping.

Example usage

"Each multinucleotide variant (MNV) within two bases was merged before consequence annotation."

Indel Single Nucleotide Variant (SNV) Variant normalization
Related-term network

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References

  • Tan A, et al. (2015). Unified representation of genetic variants. Bioinformatics.
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