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Major Allele

Definition
AI-generated

The major allele is the more frequent allele at a variant within a specified study population or dataset.

Topics
Core genetics GWAS
Related
Minor Allele Major Allele Frequency Minor Allele Frequency (MAF)

Why it matters in GWAS

Major/minor status depends on observed frequency in a given sample and can differ across cohorts. This label is about frequency ranking, not effect direction or reference-genome status.

Example usage

"The major allele in the discovery cohort was not the reference allele after liftover and harmonization."

Minor Allele Major Allele Frequency Minor Allele Frequency (MAF) Reference Allele Effect Allele
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

← MAGMA Major allele frequency →

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