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Loss of heterozygosity (LOH)

Definition
AI-generated

Somatic or germline reduction to homozygosity at a locus—often via deletion or mitotic recombination—revealed in tumor or pedigree contexts.

Topics
Core genetics
Related
Homozygosity Deletion Somatic Variant

Why it matters in GWAS

GWAS hits are interpreted through gene structure, regulation, and variant consequence; molecular vocabulary connects association statistics to mechanism.

Example usage

"Downstream interpretation uses Loss of heterozygosity (LOH) to link statistical findings to biological context."

Homozygosity Deletion Somatic Variant
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.
← Loss-of-Function Variant Low-complexity region (LCR) →

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