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Induced Pluripotent Stem Cell (iPSC)

Definition
AI-generated

An induced pluripotent stem cell (iPSC) is a pluripotent cell reprogrammed from a somatic cell (often fibroblasts or blood cells) by expression of defined transcription factors or equivalent protocols.

Topics
Molecular biology
Synonyms
iPSC
Plural
iPSCs
Related
Cell Line Cell Villages Phenotype

Why it matters in GWAS

iPSC-derived models let researchers test variant effects, regulatory programs, and drug responses in human cells with controlled genetic background, complementing primary-tissue QTL resources for interpreting GWAS mechanisms.

Example usage

"We differentiated iPSCs from carriers and non-carriers of the lead variant to assay neuronal firing phenotypes."

Cell Line Cell Villages Phenotype Transcriptome
Related-term network

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References

  • Takahashi K, Yamanaka S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell.
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