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Cell Villages

Definition
AI-generated

Cell villages are co-cultures in which induced pluripotent stem cell (iPSC) lines from many donors are differentiated together in the same dish, as opposed to parallel uni-cultures per donor.

Topics
Single-cell analysis
Related
Cohort Genome-Wide Association Study (GWAS) Single-Cell Sequencing

Why it matters in GWAS

Villages support genetic association of molecular and functional readouts in iPSC-derived models while controlling batch effects across lines, complementing primary-tissue sc-eQTL studies for interpreting GWAS mechanisms.

Example usage

"Cell villages pooled donors in one experiment to increase throughput while preserving donor-level genotype labels."

Cohort Genome-Wide Association Study (GWAS) Single-Cell Sequencing Variance Quantitative Trait Locus (varQTL)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Cuomo ASE, Nathan A, Raychaudhuri S, et al. (2023). Single-cell genomics meets human genetics. Nat Rev Genet. https://doi.org/10.1038/s41576-023-00599-5
  • Kilpinen H, et al. (2017). Common genetic variation drives molecular heterogeneity in human iPSCs. Nature.
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