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Gradient Descent

Definition
AI-generated

Gradient descent updates model parameters by stepping opposite the gradient of a loss function with respect to weights; stochastic variants estimate gradients on minibatches to scale to large datasets.

Synonyms

Why it matters in GWAS

Deep sequence or single-cell predictors used alongside GWAS pipelines depend on optimization stability; learning-rate schedules, batching, and regularization interact with whether models generalize across ancestries or labs.

Example usage

"The modeling pipeline uses Gradient Descent to improve prediction and feature interpretation before validation."

References

  • Rumelhart DE, Hinton GE, Williams RJ. (1986). Learning representations by back-propagating errors. Nature.
  • Goodfellow I, Bengio Y, Courville A. (2016). Deep Learning. MIT Press.

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