Skip to content

Drug Repurposing

Definition
AI-generated

Drug repurposing (or repositioning) applies an approved or investigational drug to a new indication—often by reusing known safety data and manufacturing—rather than discovering a molecule from scratch.

Topics
Precision medicine
Synonyms
Drug repositioning
Related
Anatomical Therapeutic Chemical Code (ATC) Genome-Wide Association Study (GWAS) Phenome-Wide Association Study (PheWAS)

Why it matters in GWAS

Genetic associations and target-level evidence (e.g. colocalization, Mendelian randomization) motivate new uses for existing compounds; biobank-scale phenotypes and PheWAS can suggest indications worth validating in trials.

Example usage

"The team prioritized drug repurposing candidates where the GWAS risk locus colocalized with drug-target expression and the compound was already on the market."

Anatomical Therapeutic Chemical Code (ATC) Genome-Wide Association Study (GWAS) Phenome-Wide Association Study (PheWAS) Precision Medicine TwoSampleMR
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Pushpakom S, et al. (2019). Drug repurposing: progress, challenges and recommendations. Nat Rev Drug Discov.
← Doubleton variant Duplicate marking →

Last updated (UTC · Git history)