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Contamination

Definition
AI-generated

Contamination is the presence of DNA from more than one source in a sample, causing distorted genotype calls and abnormal allele balance or heterozygosity patterns.

Topics
GWAS
Related
Heterozygosity Quality Control (QC) Sample Missingness

Why it matters in GWAS

Contaminated samples can generate widespread genotype error, apparent relatedness artifacts, and inflated missingness, so they are usually excluded during QC.

Example usage

"The sample showed excess heterozygosity consistent with contamination and was removed before imputation."

Heterozygosity Quality Control (QC) Sample Missingness
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Anderson CA, et al. (2010). Data quality control in genetic case-control association studies. Nat Protoc.
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