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Consensus sequence

Definition
AI-generated

A consensus sequence summarizes the most likely nucleotide (or ambiguity code) at each position from aligned reads or from an assembly graph path, representing a replicon, contig, or region after error correction and variant filtering.

Topics
Bioinformatics Sequencing Data Analysis
Related
De novo assembly Genome assembly Reference genome

Why it matters in GWAS

Consensus references and haplotype panels underpin imputation, joint calling, and pangenome graphs; how consensus is built affects allele frequencies and association tests at repetitive or low-complexity loci.

Example usage

"The viral consensus sequence was called from mapped amplicon reads with iVar."

De novo assembly Genome assembly Reference genome Variant calling
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.
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