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Assortative mating

Definition
AI-generated

Non-random pairing by phenotype or genotype—biases relatedness structure and heritability estimates.

Topics
Population genetics
Related
Homogamy Population Stratification Kinship

Why it matters in GWAS

Population structure, demographic history, and mating patterns affect allele frequencies, LD, relatedness, and cross-cohort portability—central to GWAS design and interpretation.

Example usage

"Spousal pairs in our cohort were more similar for educational attainment than expected by chance, consistent with assortative mating and potential inflation of family-based heritability estimates."

Homogamy Population Stratification Kinship
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Hartl DL, Clark AG. (2007). Principles of Population Genetics. Sinauer Associates.
  • Jobling MA, Hurles ME, Tyler-Smith C. (2013). Human Evolutionary Genetics. Garland Science.
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