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Yeast artificial chromosome (YAC)

Definition
AI-generated

Yeast vector carrying large inserts—historic clone system for long genomic fragments.

Why it matters in GWAS

GWAS hits are interpreted through gene structure, regulation, and variant consequence; molecular vocabulary connects association statistics to mechanism.

Example usage

"A replication analysis checks whether assumptions tied to Yeast artificial chromosome (YAC) remain stable across cohorts."

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.

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