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Third-generation sequencing (TGS)

Definition
AI-generated

Single-molecule long-read platforms (PacBio, Nanopore) enabling multi-kb reads and native modification detection complementing short-read arrays.

Topics
Sequencing and omics tech
Related
Long Read Sequencing Nanopore Sequencing Smrt Sequencing

Why it matters in GWAS

Bioinformatics methods determine how variants, expression, and epigenetic state are measured and summarized—shaping GWAS covariates, multi-omic integration, and functional follow-up.

Example usage

"Results report Third-generation sequencing (TGS) with uncertainty estimates to support clinical and epidemiological interpretation."

Long Read Sequencing Nanopore Sequencing Smrt Sequencing
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.
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