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Strand bias

Definition
AI-generated

Strand bias measures asymmetry in alternate-allele support between forward and reverse reads.

Topics
Sequencing Data Analysis
Related
Allele balance Sequencing artifact

Why it matters in GWAS

Strand bias is a common INFO annotation used to filter artifactual SNVs before rare-variant aggregation.

Example usage

"Variants failing the strand bias test were removed from the trusted call set."

Allele balance Sequencing artifact
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • DePristo MA, et al. (2011). A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet.
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