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Primary cell

Definition
AI-generated

Cells isolated directly from tissue with limited division capacity; contrast with immortalized cell lines.

Why it matters in GWAS

These concepts shape how we expect variants to act (penetrance, heterogeneity, threshold models) and how GWAS signals should be interpreted alongside family-based evidence.

Example usage

"Downstream interpretation uses Primary cell to connect statistical signals with biological context."

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.

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