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Multiallelic Variant

Definition
AI-generated

A multiallelic variant is a site with more than one alternative allele relative to the reference at the same genomic position.

Topics
Core genetics
Related
Biallelic Variant Alternative Allele Reference Allele

Why it matters in GWAS

Multiallelic sites complicate QC, harmonization, and meta-analysis because effect estimates and allele coding must be tracked for each alternate allele separately.

Example usage

"The multiallelic variant was split into separate biallelic records before association analysis."

Biallelic Variant Alternative Allele Reference Allele Single Nucleotide Variant (SNV) Variant Calling
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Danecek P, McCarthy SA. (2017). BCFtools/csq: haplotype-aware variant consequences. Bioinformatics.
← Multi-Trait GWAS Multidimensional Scaling (MDS) →

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