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INFO score

Definition
AI-generated

The INFO score is an imputation quality metric (related to IMPUTE’s INFO field) estimating how well-imputed a variant is, often between 0 and 1 with higher values indicating better recovery of genotypes.

Topics
Sequencing Data Analysis
Related
Genotype Imputation Imputation Quality Metric

Why it matters in GWAS

INFO thresholds reduce noise from poorly imputed variants in array-based GWAS; analogous metrics exist for sequencing-based imputation.

Example usage

"Association tests retained variants with INFO score > 0.8 after imputation."

Genotype Imputation Imputation Quality Metric
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Howie BN, et al. (2009). A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet.
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