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Homopolymer

Definition
AI-generated

A homopolymer is a run of identical bases (for example AAAA).

Topics
Sequencing Data Analysis
Related
Indel Low-complexity region

Why it matters in GWAS

Indel artifacts cluster in homopolymers; masks and local realignment reduce false positives in WGS call sets.

Example usage

"Indels in homopolymer runs were flagged for orthogonal validation."

Indel Low-complexity region
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Koboldt DC. (2020). Best practices for variant calling in clinical and population sequencing. Nat Methods.
← Homology-directed repair (HDR) Homozygosity →

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