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Differential Missingness

Definition
AI-generated

Differential missingness occurs when genotype call failure differs systematically between comparison groups, such as cases and controls.

Topics
Epidemiology
Related
Batch Effect Quality Control (QC) Variant Missingness

Why it matters in GWAS

It can induce false associations because missingness becomes correlated with phenotype rather than occurring at random.

Example usage

"We removed SNPs with significant case-control differential missingness before the main association analysis."

Batch Effect Quality Control (QC) Variant Missingness
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Anderson CA, et al. (2010). Data quality control in genetic case-control association studies. Nat Protoc.
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