Skip to content

Collapsing analysis

Definition
AI-generated

Collapsing analysis aggregates rare variants within genes or masks into a single unit for association—often analyzed with burden or dispersion tests.

Topics
Sequencing Data Analysis
Related
Burden Test Functional mask Rare Variant Aggregation Test

Why it matters in GWAS

Collapsing is standard for WGS rare-variant association when per-variant power is negligible.

Example usage

"Gene-level collapsing analysis was performed with a LoF-only mask and SKAT-O."

Burden Test Functional mask Rare Variant Aggregation Test
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Basu S, Pan W. (2011). Comparison of statistical tests for association with rare variants. Genet Epidemiol.
← Cohort study Collider Bias →

Last updated (UTC · Git history)