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Chain-of-Thought (CoT)

Definition
AI-generated

Chain-of-thought (CoT) prompting asks a language model to emit intermediate reasoning steps before a final answer—often improving multi-step problems in math, logic, or structured extraction—at the cost of longer generations and sensitivity to prompt phrasing.

Synonyms

Why it matters in GWAS

Structured pipelines (field mapping, ontology alignment, or allele checks) sometimes use CoT-style scratchpads; outputs should still be validated against schemas and primary data because verbose reasoning can look plausible while wrong.

Example usage

"We added a CoT block that lists column harmonization steps before emitting the JSON, which reduced stray delimiter errors in the trait table."

References

  • Wei J, et al. (2022). Chain-of-thought prompting elicits reasoning in large language models. NeurIPS.

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