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Nonsense-mediated decay (NMD)

Definition
AI-generated

Surveillance eliminating mRNAs with premature stop codons; modulates severity of nonsense variants.

Topics
Molecular biology
Related
Nonsense Variant Splice Site Variant Exon

Why it matters in GWAS

GWAS hits are interpreted through gene structure, regulation, and variant consequence; molecular vocabulary connects association statistics to mechanism.

Example usage

"Downstream interpretation uses Nonsense-mediated decay (NMD) to link statistical findings to biological context."

Nonsense Variant Splice Site Variant Exon
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.
← Noncoding Variant Nonsense Variant →

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