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Hard clipping

Definition
AI-generated

Hard clipping removes bases from a read record entirely (not present in SEQ), unlike soft clipping.

Topics
Sequencing Data Analysis
Related
Soft clipping

Why it matters in GWAS

Hard-clipped records affect length-based metrics and may interact with duplicate detection; analysts should track whether FASTQ trimming preceded alignment.

Example usage

"Hard clipping removed primer sequence from supplementary alignments before discordant clustering."

Soft clipping
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Li H, et al. (2009). The Sequence Alignment/Map format and SAMtools. Bioinformatics.
← HapMap Project Hard filtering →

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