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Dicentric chromosome

Definition
AI-generated

Abnormal chromosome with two centromeres, often unstable during segregation.

Topics
Molecular biology
Related
Centromere Structural Variant Chromosome

Why it matters in GWAS

GWAS hits are interpreted through gene structure, regulation, and variant consequence; molecular vocabulary connects association statistics to mechanism.

Example usage

"Cytogenetic review identified a Dicentric chromosome in one case sample with complex rearrangements."

Centromere Structural Variant Chromosome
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.
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