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Combined Annotation Dependent Depletion (CADD)

Definition
AI-generated

Integrative pathogenicity score combining many functional annotations to rank SNVs and small indels; higher scores suggest more deleterious impact.

Topics
Post-GWAS
Related
Variant Annotation Missense Variant Loss Of Function Variant

Why it matters in GWAS

Bioinformatics methods determine how variants, expression, and epigenetic state are measured and summarized—shaping GWAS covariates, multi-omic integration, and functional follow-up.

Example usage

"Lead variants were ranked by CADD scores to prioritize potentially deleterious candidates for functional follow-up."

Variant Annotation Missense Variant Loss Of Function Variant
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.
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